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World Molecular biology and R&D Summit
October 23-24, 2017 Toronto, Canada
Molecular Biology 2017 aims to shed focus on the translational nature of biotechnological research, with emphasis on both the basic science as well as its applications in industry and academia. Latest researches, agricultural Molecular Biology, business models, pharmaceutical Molecular Biology, medical Molecular Biology, cancer biology, immunology, genetics, protein engineering, plant and environmental technologies, transgenic plant and crops, bioremediation, and microbial diversity research will be the subjects of discussion.
Target Audience for Molecular Biology Conference will be personnel from both industrial and academic fields which include; Directors/Managers, Head of Departmental, Presidents/Vice Presidents, CEO, Professors, Associate and Assistant professors, Research Scholars and students from the related fields.
Molecular Biology is an interdisciplinary subject in biology it is a combination of subjects like Biochemistry, Genetics, Bioinformatics, Computational biology. It deals with the molecular activity processes like replication, transcription, translation, and cell function. Various Emerging Technologies were developed in Molecular biology those are like 1) Organic electronics 2) Nutrigenomics Redox 3) Signaling Technology
Molecular Biochemistry is the study of the molecular mechanisms by which genetic information encoded in DNA is able to result in the processes of life. Molecular Biochemistry has developed widely to capture the array of chemistry, physics, medicine and biology. It is one of the most important aspects of molecular biology to discover the chemical properties of the molecules. The kind various processes that occur within the cell are responsible for their structure, reproduction and response to stimuli. In medicine, Molecular biochemists investigate the causes and cure of diseases. In nutrition, they study how to maintain health and side effects of nutritionaldeficiencies. In agriculture, Molecular biochemists investigate soil and fertilizers, and try to discover a new solutions or new techniques to improve crop cultivation, crop storage and pest control.
Modern genetics has expanded beyond inheritance to study the function and behavior of genes and gene structure and function, variation, and distribution are studied within the context of the cell, the organism and within the context of the population Genetic engineering is the process of manually adding new DNA to an organism. The goal is to add one or more new traits that are not already found in that organism (or) Genetic engineering alters the genetic make-up of an organism using techniques that remove heritable material or that introduce DNA prepared outside the organism either directly into the host or into a living cell that is then fused or hybridized with the host. Example of genetically modified foods and plants such as genetically modified corn (resistant to the herbicide Glyphosate ) , genetically engineered soy, Yellow Crookneck Squash and Zucchini, Alfalfa, Sugar Beets.
Proteinengineering is the process or a procedure of developing useful or valuable proteins. It is an interdisciplinary subject in the field of life sciences in this study of various kind of protein structures, interactions, protein folding and also designing of protein principles can be done. There are to two are present for protein engineering those are
A. Rational protein design
B. Direct evolution design
Genomics is the study of entire genomes and theirs roles, function, importance and related techniques in inheritance. Genomics also involves in study of intra genomic processes like epistasis, pleiotropy and as well as the interactions between loci and alleles within the genome. Genomics has the potential of offering new therapeutic methods for the treatment of some diseases, as well as new diagnostic methods. Genomics involves the study of all genes at the DNA, mRNA, and proteome level as well as the cellular or tissue level.
Proteomics is large the scale study of a specific proteome, including information on protein abundances, their variations and modifications, along with their interacting partners and networks.
RNA-based therapeutics can be classified based on the mechanism of activity, and it include inhibitors of mRNA translation, the agents of RNA interference (RNAi), catalytically active RNA molecules, and RNAs that bind proteins and other molecular ligands. RNA therapeutics have improvements in synthetic and natural nucleic acid carriers and the development of chemically modified oligonucleotides. RNA-based therapeutics currently under clinical investigation for diseases like genetic disorders, HIV infection, and various cancers. RNA is inherently unstable, mostly immunogenic, and requires a delivery vehicle for efficient transport to the targeted cells. RNA-based therapeutics that broaden the range of “drug-able” targets beyond the scope of existing pharmacological drugs.
Cell signaling is the process of communication that governs the basic activities of cells and coordinates cell actions. endocrine signaling by hormones. They may respond to molecules on the surface of adjacent cell. Signaling molecule may trigger immediate change in the metabolism of the cell. Chemotherapy is treatment in which medicines and drugs are used to treat the cancer disease (or) chemotherapy is treatment process in which distraction of cancer cells takes place. Chemotherapy may also include the use of antibiotics other medications to treat any illness or infection.
Tissue Engineering can be defined as use of living cells, material and engineering methods, and use of biochemical factors and physicochemical factors, to improve or replace the biological tissues. The main aim of the tissue engineering is to assemble functional constructs that restore, maintain, or improve damaged tissues or whole organs. This field mainly focuses on cures instead of treatments for complex diseases or chronic diseases. Genome Engineering can be defined as use of engineering methods to modify or to replace the genetic information of the genome of a living organism. This field have many application in fields like human health, agriculture biotechnology( to produce genetically modified crops and plants), in the production of therapeutic proteins, in production of genetically modified organisms(transgenic sheep, pig, mouse etc),in applied biological research.
Bioinformatics is an interdisciplinary field of science it develops the methods and software tools for an understanding of biological data. It is combination subjects like computer science, statistics, mathematics, and engineering. It is has been used in in silico analyses of biological queries using mathematical and statistical techniques. The uses of bioinformatics include the identification of particular or specific genes and nucleotides of a living organism, used for identification of differences between the population, and also used for phylogenetic tree analysis and used for better understanding the genetic basis of diseases. Drug design is an invite process finding new medication on the basis of biological target. It is also called as rational drug design or rational design that is an invitation order to yield significant therapeutic response. The drug design involves the design of molecules that are similar to the bio molecular target site in shape or structure and charge in order to bind to it.
ComputationalMolecular Biology is an interdisciplinary subject in field of science it mainly focuses on the computational, statistical, experimental, and technological methods, which is accelerating the discovery of new technologies and tools for molecular biology. In computational molecular biology we can understand the major issues concerning analysis of genomes, sequences and structures of molecules. It also focuses on sequence alignment algorithms, dynamic programming, hashing, suffix trees, and Gibbs sampling, and computational approaches to, genetic and physical mapping, genome sequencing, assembly, RNA expression and secondary structure, protein structure and folding, and molecular interactions and dynamics
In Molecular Biology several techniques are used those are given below
1) Molecular cloning or Expression cloning 2)Polymerase Chain Reaction 3)Gel electrophoresis 4) Macromolecule blotting
Rare diseasesand Undiagnosed diseases are the diseases that affects the small number of people or small percentage of population. Many rare diseases appeared early in life, and about 30 percent of children with rare diseases will die before reaching their 5th birthday. These are mostly geneticdisorders. Next-generation sequencing (NGS) technology is used to discover the Rare and Undiagnosed Diseases.
MitochondrialGenetics is the study of genetics of mitochondrial DNA. In most multi cellular organisms, mitochondrial DNA is inherited only from the mother's ovum. Mitochondrial DNA mutations lead to functional problems, which may causes muscle disorders. Mitochondrial DNA is used in electron transport chain, replication, transcription, and translation. Mitochondrial disease is principally a chronic loss of cellular energy, Mitochondria is responsible for creating more than 90% of the energy needed by the body to sustain life and to support organ function.
In the past, Molecular Biology concentrated on the production of food and medicine. It also tried to solve environmental problems. In the nineteenth century, industries linked to the fermentation technology had grown tremendously because of the high demand for various chemicals such as ethanol, butanol, glycerine, acetone, etc. The advancement in fermentation process by its interaction with chemical
Engineering has given rise to a new area—the bioprocess technology. Large-scale production of proteins and enzymes can be carried out by applying bioprocess technology in fermentation. Applying the principles of biology, chemistry, and engineering sciences, processes are developed to create large quantities of chemicals, antibiotics, proteins, and enzymes in an economical manner. Bioprocess technology includes media and buffer preparation, upstream processing and downstream Processing. This has led to the division of Molecular Biology into different areas such as agricultural Molecular Biology, medical or pharmaceutical Molecular Biology, industrial Molecular Biology, and environmental Molecular Biology.
Canada is currently focusing on interest in Molecular Biology enterprises practicing both in human wellbeing for the tropics, Genetics, Biochemistry, Bioinformatics, Medicine, Molecular immunology, Computational biology, Biotechnology. In a world commanded by northern half of the globe medicate organizations concentrating on the wellbeing needs of higher-pay countries; these two parts constitute a less aggressive field for Canada to endeavor the cutting edge strength that has since quite a while ago escaped the country. With most spaces on the innovative chessboard, for example, IT and programming as of now completely involved by US, European or propelled East Asian countries, Molecular biology could be Canada's "next huge thing" in the years to 2020. Thousands of foreign students from more than 160 countries and regions attend the University ofToronto. In a recent year, the top countries of origin for non-Canadian students were China, India and the U.S. Tuition is higher for international students. Canada publishing most of the publication on molecular biology than any other country it was ranked in first in the world.
Molecular biology is one of the most prior sectors in Canada, and continues to significant expansion. Canada has built an exceptionally strong Molecular biology and Molecular medicines sectors. The Molecular biology market in Canada is equally astonishing, comprised of a strong scientific base, abundant natural resources, growing population. Together, these trends have more demand for health care services. Most public and private laboratories invest their resources in research towards new solutions for the production of medicines for various kind of diseases like Alzheimer’s, Huntington’s disease, muscular dystrophies, and smallpox, cholera and typhoid fever, and gastrointestinal infections and gastric ulcers, transgenic and sustainably-produced food.
The molecular biology enzymes and kits & reagents market is projected to reach USD 12.69 Billion by 2021 from USD 5.77 Billion in 2016, growing at a CAGR of 17.1% during the forecast period of 2016 to 2021. Growth in molecular biology enzymes and kits & reagents market can be attributed to the technological advancements in the life science industry. Growth in molecular biology enzymes and kits & reagents market can be attributed to the technological advancements in the life science industry, increased research activities in the pharmaceutical and biotechnology sector, rising incidences of infectious diseases and genetic disorders, and successful completion of human genome project. On the other hand, privacy issues related to genetic information and unfavorable reimbursement scenario for genetic testing are expected to restraint the molecular biology reagents market growth during the forecast period.
Molecular Biology products represented 21% of the total $714bn global market for prescription drugs in 2012, equating to $150bn of sales. The size of the prescription drugs market is expected to grow at a CAGR of 3.8% to reach $895bn in 2018, and the Molecular Biology industry’s share of this is expected to grow to 25%, equivalent to $224bn. This represents a CAGR of 6.9% for the biotechmarket, higher than the growth of aggregate pharmaceutical industry because Molecular Biology products have a less aggressive rate of sales erosion from generic drugs
- University of Toronto, Canada
- McGill University, Canada
- University of British Columbia, Vancouver, Canada
- University of Montreal, Canada
- Harvard University, Massachusetts, United States
- University of California, San Francisco, United states
- University of Cambridge, United States
- Stanford University, California, United States
- University of Oxford, United States
- Massachusetts Institute of Technology, United States
- University of Washington, Seattle, United States
- University College London, United Kingdom
- University of Melbourne, Australia
- Arbutus Biopharma, Canada
- FUJIFILM Visual Sonics, Inc, Canada
- Johnson & Johnson, New Jersey, United States
- Pfizer Pharmaceutical, New York City, United States
- Novartis, Basel, Switzerland
- Amgen, California, United States
- Sanofi Pharmaceuticals, France
- Hoffmann-La Roche, Basel, Switzerland
- AbbVie Inc., United States
- Bristol-Myers Squibb, New York, United States
- GlaxoSmithKline, London, United Kingdom
- Bayer, Leverkusen, Germany
- Biogen, Massachusetts, United State
- Stryker Corporation, United States
- Alexion Pharmaceuticals, New Haven, United States
- American Society for Biochemistry and Molecular Biology
- EFPIA European Federation of Pharmaceutical Industries and Associations
- American Institute of Biological Sciences(AIBS)
- American Society for Cell Biology
- The German Society for Biochemistry and Molecular Biology
- Federation of European Biochemical Societies
- American Chemical Society
- Association for Molecular Pathology(AMP)
- American Association of Bio analysis- Molecular/Genetic Testing
- Molecular Biology Association Search Form- CGAP
- Association of Genetic Technologies
- Molecular Biology Student Association
- Association for Clinical Genetic Science
- International Federation of Human Genetics Societies
- Society for Molecular Biology and Evolution